Asian woman with a headscarf sits laughing with her legs bent in a living room. Lettering: "desire to have children and cancer", "medimentum".

Desire to have Chil­dren and Cancer

Can­cer ther­a­pies can lim­it fer­til­i­ty. This applies to all gen­ders. In this post, we explain the woman’s per­spec­tive and why it is very impor­tant to take fer­til­i­ty preser­va­tion mea­sures before can­cer treat­ment. If there is a desire to have chil­dren, it should be con­sid­ered that can­cer ther­a­py can have an impact on fam­i­ly planning.

Thanks to med­ical advances, mod­ern can­cer treat­ment options are now avail­able that sig­nif­i­cant­ly improve the long-term out­comes of can­cer patients. This also rais­es ques­tions about the desire to have chil­dren. About 10 per­cent of women with can­cer are under the age of 40. So, med­ical­ly, they are of child­bear­ing age. How­ev­er, many can­cer ther­a­pies are asso­ci­at­ed with a direct or indi­rect reduc­tion in or even loss of fer­til­i­ty. The lat­est devel­op­ments in the field of repro­duc­tive med­i­cine enable effec­tive, fer­til­i­ty-pre­serv­ing mea­sures in the con­text of can­cer therapy.

Impor­tant facts

Imme­di­ate­ly after the diag­no­sis, young can­cer patients are often con­front­ed with the ques­tion of whether they want to start a fam­i­ly or have more chil­dren. This is because the treat­ment that helps you beat can­cer may also affect your abil­i­ty to repro­duce. This leads to a sit­u­a­tion in which time is of the essence. There­fore, it is impor­tant to deal with the sub­ject of the desire to have chil­dren before start­ing therapy.

Can­cer cells divide uncon­trol­lably and grow beyond the nat­ur­al bound­aries of the organ. Sub­se­quent­ly, many indi­vid­ual cells togeth­er form what is known as a tumor, which can also be referred to as a tumour. A woman’s fer­til­i­ty can be affect­ed for a vari­ety of rea­sons. On the one hand, tumors can affect the sex organs direct­ly (e.g. in uter­ine or ovar­i­an can­cer). On the oth­er hand, the cor­re­spond­ing ther­a­py can have a neg­a­tive effect on fer­til­i­ty. Not only the chemother­a­py, but also the oper­a­tion or any radi­a­tion or hor­mone ther­a­pies can cause direct (e.g. dam­age to egg cells) and indi­rect effects such as phys­i­cal weak­ness (fatigue). Psy­cho­log­i­cal fac­tors also play a spe­cial role in deal­ing with a can­cer diagnosis.

Influ­ence of can­cer ther­a­py on fam­i­ly planning

What are the effects of can­cer treat­ments, such as surgery, radi­a­tion or chemother­a­py, on fer­til­i­ty? In par­tic­u­lar, oper­a­tions on the female repro­duc­tive organs (womb, cervix or ovaries) can impair a woman’s fer­til­i­ty and, in the worst case, also mean that preg­nan­cy can no longer occur. The influ­ence depends on the can­cer and the required ther­a­py. In prin­ci­ple, oper­a­tions in the abdomen and pelvis that do not direct­ly affect the female gen­i­tal organs can also have a neg­a­tive impact on repro­duc­tive capac­i­ty. In women, for exam­ple, scar­ring and adhe­sions can pre­vent preg­nan­cy and lead to pre­ma­ture birth or miscarriage.

The drugs used in chemother­a­py, so-called cyto­sta­t­ics, inter­vene more or less direct­ly in cell divi­sion. Since the cyto­sta­t­ics do not dis­tin­guish between healthy and affect­ed cells, not only the can­cer cells are destroyed, but also intact cells. For exam­ple, the ovaries can be affect­ed. The drugs have dif­fer­ent effects on fer­til­i­ty. In addi­tion to the sub­stance, the dose is also deci­sive for the effect on fer­til­i­ty. The bio­log­i­cal fac­tor of age also plays a role: the old­er a woman is, the more like­ly it is that she will become infer­tile as a result of the treatment.

Preser­va­tion of fer­til­i­ty in the case of cancer

Until a few years ago, there were almost no fer­til­i­ty-pre­serv­ing options for women. Mean­while — due to rapid progress in repro­duc­tive med­i­cine — there are ways to ful­fill the desire to have chil­dren despite can­cer. For­tu­nate­ly for women up to the age of 40 there are dif­fer­ent options depend­ing on the begin­ning and type of can­cer treat­ment for the patient. For exam­ple, fer­til­ized egg cells or removed ovar­i­an tis­sue can be frozen and thus pre­served. If the con­di­tions are right, sev­er­al fer­til­i­ty-pre­serv­ing mea­sures can even be car­ried out to increase the chance of hav­ing a child. In addi­tion, sup­port­ive mea­sures such as nutri­tion should also be tak­en into account.

Nutri­tion and Fertility

In gen­er­al, can­cer patients do not require a spe­cial diet. There are indi­ca­tions of unfa­vor­able influ­ences from nutri­tion, e.g. exces­sive con­sump­tion of refined sug­ar and fat, which can play a role in the devel­op­ment of can­cer. How­ev­er, there is no clear study on this yet. In prin­ci­ple, how­ev­er, affect­ed women should pay atten­tion to their diet. For exam­ple, con­sid­er­ing the fol­low­ing five points:

  1. Plea­sure & time — You should take enough time to eat in a com­fort­able atmos­phere. Spices and fla­vors should also be expe­ri­enced consciously.
  1. Alco­hol and Nico­tine — Alco­hol should be con­sumed in mod­er­a­tion at most. Nico­tine should be avoid­ed entirely.
  2. Weight — Over­weight and under­weight should be avoided.
  3. Serv­ing Size — If you are of nor­mal weight or tend to be over­weight, you should eat 3 main meals with no snacks in between. If you are los­ing weight, snack­ing between meals can be useful.
  4. Food pyra­mid — The food pyra­mid from the Fed­er­al Cen­ter for Nutri­tion offers a use­ful orientation.

Con­clu­sion

The diag­no­sis »can­cer« is always an extreme sit­u­a­tion for those affect­ed and their rel­a­tives. This leads to count­less ques­tions for those affect­ed about prog­no­sis, diag­nos­tics, ther­a­py and after­care. There are also many ques­tions on the usu­al­ly taboo sub­ject of want­i­ng to have chil­dren with can­cer, but too lit­tle time is often giv­en to them in every­day clin­i­cal prac­tice. In the mean­time, there is expe­ri­ence on the sub­ject of the desire to have chil­dren for almost all types of gyne­co­log­i­cal can­cer. Nev­er­the­less, the data sit­u­a­tion is very lim­it­ed, since the dis­eases are very rare and the cas­es are usu­al­ly very com­plex. You need indi­vid­ual advice. There­fore, there is still a great need for research.

Sources

Fed­er­al Cen­ter for Nutri­tion
bzfe.de

krebsgesellschaft.de
https://www.krebsgesellschaft.de/

Dr. med. Andreas Jan­tke
KINDERWUNSCHÄRZTE BERLIN

Gyne­col­o­gy Clin­ic and Poly­clin­ic
Uni­ver­si­ty Hos­pi­tal Hamburg-Eppendorf

Health City Berlin
https://www.gesundheitsstadt-berlin.de/

Deutsche Kreb­shil­fe e.V.

Fer­tipro­tekt
http://www.fertiprotekt.de

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